A bioRxiv paper using Spy-VLP mosaics against various coronaviruses.
Click here for the paper (12 February, 2021).
Wang et al. show RBD display on Ferritin particles using SpyTag / SpyCatcher technology.
Click here for the paper (23 December, 2020).
Ma et al. from the Institute of Human Virology in Guangdong construct two Ferritin-based nanoparticle vaccines that conjugate RBD and HR antigens in SARS-CoV-2 Spike protein utilizing the SpyTag/ SpyCatcher system. RBD and RBD-HR nanoparticles vaccines elicit more potent neutralizing antibody responses and stronger T cell immune responses than monomers. HR-containing nanoparticles induce cross-reactive immune responses against other coronaviruses
Click here for the paper (25 November, 2020).
A study from Scripps using the SpyTag/SpyCatcher technology.
Click here for the paper (18 November, 2020).
Zhang et al. show that SpyTag/SpyCatcher can be used on lumazine synthase or ferritin and applied for display of RSV trimer or SARS-CoV-2 spike.
Click here for the paper (23 October, 2020).
George Lomonossoff at the John Innes Centre demonstrates production of Hepatitis B Virus Core antigen VLPs in Nicotiana benthamiana (a relative of tobacco) and conjugation to an HIV capsid protein.
Click here for the paper (13 October, 2020).
A study from Scripps using SpyTag/SpyCatcher technology shows that the receptor-binding domain and stabilized SARS-CoV-2 spike displayed on ferritin nanoparticles as vaccine antigens, elicited potent immune responses.
Click link here for the paper (14 September, 2020).
Covid-19 vaccine candidates using SpyCatcher/SpyTag to display Spike protein on computationally designed particles and Bacteriophage VLPs.
Click here to read the full paper on computationally designed VLPs (31 August, 2020).
Click here to read the full paper on Bacteriophage VLPs.