SpyBiotech have developed unique technology to transform how vaccines are created.
- Unique access to protein superglue for vaccines: SpyTag/SpyCatcher
- Rapid and irreversible linkage of antigen to virus-like particle platform
- Specific assembly to give an optimal focused immune response
- Applicable to a wide range of infectious diseases (viral, bacterial, parasitic) and potentially to cancer
Vaccines are one of the most successful of all medical interventions. The best vaccines can make a disease disappear. One of the most effective ways to create a vaccine is to make a particle that looks like a virus. Virus-like particles look like a virus on the outside but do not contain any viral genetic material, so they cannot cause disease. If virus-like particles can be decorated uniformly with a protein from the disease-causing organism, the body will raise high levels of antibody to this protein, which protects against infection.
This process of decoration has been a central limiting factor, holding back vaccine generation: sometimes it takes many years and sometimes it has previously proved impossible.
SpyTag/SpyCatcher provides a solution: Plug-and-Protect™ vaccine production.
SpyTag is a peptide that reacts irreversibly with its protein partner SpyCatcher. Both SpyTag and SpyCatcher can be made in any cell-type. SpyTag/SpyCatcher reaction is fast, efficient and specific.
SpyBiotech fuses SpyCatcher to virus-like particles. Then, after identifying a viral or bacterial target, we only need to fuse this target to SpyTag, mix with the particles, and the vaccine is ready to use.
Selected Publications (open access)
Brune KD, Leneghan D, Brian IJ, Ishizuka AS, Bachmann MF, Draper SJ, Biswas S, Howarth M.
Sci Rep 2016 Jan 19;6:19234.
Reddington SC, Howarth M.
Curr Opin Chem Biol. 2015 Oct 27;29:94-99
Veggiani G, Nakamura T, Brenner MD, Gayet RV, Yan J, Robinson CV, Howarth M.
PNAS 2016 Feb 2;113(5):1202-7
Zakeri B, Fierer JO, Celik E, Chittock EC, Schwarz-Linek U, Moy VT, Howarth M.
PNAS 2012 Mar 20;109(12):E690-7.
SpyTag technology has application across a range of diseases and vaccine platforms. We are keen to partner with other companies to develop these opportunities, so please get in touch.